Biologist, BTA as Senior Research Associate - Oncology, Cell Culture, Immunotherapies

Job ID:3106542129

Senior Research Associate - Oncology Discovery

Job facts

Job function



Switzerland, Basle-Town, Basle





Job type

Regular Employee

Job level

Individual Contributor


Roche Pharmaceuticals



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Work location:

Basel; Contact HR: K.Arnold

The Oncology Discovery and Translational Area (DTA) of Roche Pharmaceutical Research & Early Development (pRED) is building a new Small Molecules Oncology research group in the Roche headquarters in Basel which will focus on the discovery of novel targets, mechanism and approaches in the area of cancer genomics/signal transduction and combinations therapies, including cancer immunology targets. We are seeking two exceptional, highly motivated, and talented research associates to join our cancer biology team focused on the discovery of novel small molecule targets as innovative cancer therapies in the field of cancer immunotherapy. As a member of the Oncology Small Molecule Discovery group you will interact with a team of approximately 25 cancer biologists supported by Roche’s Small Molecule Research (SMR) and Pharmaceutical Sciences (PS) functions to evaluate candidate therapies by a state-of-the art molecular, cellular and in vivo pharmacology laboratory set up. In this role, you will have some of these responsibilities:

  • Isolate cells and establish primary cell culture from murine tissues/organs and human peripheral blood or tumor infiltrating lymphocytes, maintain in vitro cell cultures
  • Perform flow cytometry-based phenotypic and functional analyses
  • Characterize immune cell phenotype and function by multicolor flow cytometry, ELISA/ELISPOT and imaging
  • Develop and perform assays to evaluate the effect of candidate small molecule immunotherapies upon human immune cell function
  • Analyze data and present results
  • Share knowledge by enthusiastic collaboration with other scientists and technicians inside and outside the group
  • Have laboratory manager responsibilities including daily lab routine, ordering supplies, monitoring inventory and contracts

Who you are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

You have a Bachelor’s or a Master’s degree, or an apprenticeship as Lab technician with research experience in cell biology/immunology with at least 3 years of experience. You are well organized and committed to formal record keeping, a team player, and you foster a collaborative spirit with scientist and technician colleagues. You can adapt to a fast-paced, changing environment, are fluent in English and have good presentation and communication skills. In addition, you bring one or more of the following:

  • Experience in a range of cell culture techniques including development of assays for screening formats
  • Experience with tumor cell/ immune cell cultures and co-cultures, various cell biology techniques and state-of-the art immunoprofiling techniques for functional characterization of immune cell responses (analysis by flow cytometry, MACS sorting, ELISA, luminescence
  • Hands-on experience with in vitro peripheral blood mononuclear cell (PBMC)-based assays
  • Immunofluorescense analyses and confocal microscopy experience
  • Experience in a range of biochemical techniques including western blot and immunoprecipitation
  • Experience with siRNA/shRNA or CRISPR technologies is an advantage

Please note, candidates with a PhD can not be considered for this position.

Who we are

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 8,500 people from approximately 90 countries work in Basel, which is one of Roche`s largest sites. Read more.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

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