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PhD student position in Biochemistry and Molecular Biology

Function and mechanism of ATP-dependent nucleosome remodeling factors

The topic:
ATP-dependent nucleosome remodeling machines are conserved enzymes that transform the structure and function of eukaryotic chromatin. Some remodeling enzymes can deposit or evict nucleosomes; others reposition entire nucleosomes along DNA. Collectively they enable critical switches in the structural state of chromatin that are needed during development or upon environmental changes. 

Despite intense research, the mechanism of nucleosome remodeling has remained elusive. In particular, it is unclear how dense heterochromatin can be remodeled. We approach this long-standing question by protein biochemistry (FPLC, quantitative enzyme assays), yeast genetics and genomic approaches (e.g. ChIP-Seq). 

The group:
The Mueller-Planitz group is based in Munich, Germany, and is part of the Molecular Biology Department of the newly-built BioMedical Center of the Ludwig-Maximilians-Universität. The group is currently funded by three DFG grants and is part of the SFB 1064 initiative “Chromatin dynamics”. A variety of in-house core facilities guarantees access to state-of-the-art equipment.

Who you are:
You are someone with excellent scientific and organizational skills. You are fully committed to science, and enjoy testing and challenging your hypotheses. You have good communication skills, and you are proficient in oral and written English. Teamwork comes natural to you. We expect outstanding motivation, critical and analytical thinking and a strong scientific enthusiasm. You have an M.Sc. degree in a relevant field, e.g. Biochemistry or Molecular Biology, and a broad interest in mechanisms at the molecular level and in chromatin biology.

How to apply:
Please send your application and a list of references to fmp.applications@med.uni-muenchen.de using the reference code #JV15. Please include your university transcripts and your motivation for joining the group in your application.

Initial Deadline: October 6th, 2015, but the call will remain open until the position is filled.

The Ludwig-Maximilians-Universität is an Equal Opportunity Employer.

How to apply:
Please send your complete application by EMail and provide the reference number of this ad.
Kontakt für Bewerbungen
Felix Mueller-Planitz 
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: JV15

Über Ludwig Maximilians Universität München

We are an independent junior research group embedded in the Department of Molecular Biology (chair Prof. Dr. Peter B. Becker) at the Adolf-Butenandt-Institut, LMU München. Our group studies the mechanisms of nucleosome remodeling using biochemical, biophysical and structural methods. The enormous size of eukaryotic genomic DNA necessitates elaborate mechanisms for its...

Mehr über die Ludwig Maximilians Universität München

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