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PhD Position: Regulation and functions of alternative splicing in plant development and stress responses

Starting from June 2015 or at the earliest possible date, a PhD position in a research project analyzing regulatory mechanisms and physiological functions of alternative splicing in plants will be available in the research group Wachter at the Center for Plant Molecular Biology in Tübingen.

Our group is mainly interested in the regulation and functional implications of alternative splicing in plants. We combine transcriptome-wide alternative splicing analyses with detailed, mechanistic studies of splicing regulation to define the functions of this widespread gene-regulatory mechanism in plant development and stress responses. Frequently used techniques in our projects include RNA-sequencing, in vivo splicing assays, RNA/protein and protein/protein in vitro and in vivo interaction studies, protein localization experiments, and generation and physiological studies of plant mutants. Most of our work is based on the model organism Arabidopsis thaliana.
The project advertised here is based on our previous work identifying Polypyrimidine Tract-binding proteins (PTBs) as major regulators of alternative splicing in Arabidopsis thaliana. One major goal is to define positions and sequences of PTB binding motifs using in vitro RNA/protein interaction assays and in vivo splicing reporter assays. Furthermore, PTB mutants show developmental changes as well as enhanced drought resistance compared to wild type plants, and this project aims at defining the molecular basis of these intriguing phenotypes. For further information on the research and publications from our group, please visit our web page:


Applicants need a master or diploma in biology or related fields and should be highly motivated to work in basic research. Furthermore, experience in plant molecular biology and/or RNA research is expected. The project will benefit from an excellent scientific environment, state of the art equipment and central facilities in a brand-new building, and a graduate program at the Center for Plant Molecular Biology. Salary is according to TV-L E13 (65%) and is available for initially three years.
Applications should include motivation letter, CV, certificates, publication list if applicable, and names and contact information of two references. Please send your application by e-mail to awachter@zmbp.uni-tuebingen.de (directed to Dr. Andreas Wachter).
How to apply:
Kontakt für Bewerbungen
Please send your application by e-mail to awachter@zmbp.uni-tuebingen.de (directed to Dr. Andreas Wachter).
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: 2015-04-30

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RNA-mediated gene control

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