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Ph.D. Position in Molecular Cell Biology

 Universität Heidelberg  69120 Heidelberg
Ph.D. position:
“Structure and dynamics of the endoplasmic reticulum during mitosis”
Centre for Molecular Biology (ZMBH), University of Heidelberg
Background During mitosis, eukaryotic cells coordinately remodel their microtubule cytoskeleton and their membrane-bound organelles. The transformation of the microtubule cytoskeleton into the bipolar mitotic spindle is well investigated. In contrast, the mechanisms and functions of mitotic organelle restructuring have so far largely remained elusive. We previously identified new potential mediators of organelle remodeling during mitosis, among them the endoplasmic reticulum (ER)-microtubule linkers REEP3 and REEP4. REEP3/4 control the distribution of the ER during mitosis in a microtubule-dependent manner. In addition, REEP3/4 function is critical for proper nuclear envelope morphology, fidelity of chromosome segregation, and correct cytokinesis (Schlaitz et al., Dev Cell 2013). Another approximately 50 new candidate remodelers were isolated, a number of which are required for successful mitosis.
Thesis project The successful applicant will investigate the molecular mechanisms of REEP3/4 function as well as REEP3/4 interplay with the mitotic machinery. Furthermore, previously uncharacterized candidate remodelers will be screened for their roles in mitosis. This project will uncover unappreciated mitotic pathways and thus enable a more comprehensive understanding of this fundamental biological process.
Methods used will include high-resolution imaging coupled with quantitative image analysis, biochemical assays and molecular biology methods. Biological models in the lab are mammalian tissue culture cells and the nematode C. elegans .
Requirements Applicants should hold a Master’s degree in Molecular Biology, Life Sciences, Biochemistry or a related field, have a solid background in molecular cell biology and a keen interest to acquire and apply image analysis skills. An enthusiastic student with a passion to understand the molecular makeup of cells and who enjoys working in a collaborative and international environment will be an ideal addition to our newly established group.
Earliest start date is June 1st 2015.
Please apply by email (a.schlaitz@zmbh.uni-heidelberg.de) and include in one single PDF file your CV, copies of certificates and contact information for two referees.
Please refer to the lab website for further information: http://www.zmbh.uni-heidelberg.de/schiebel/schlaitz/default.shtml
How to apply:
Please apply by email (a.schlaitz@zmbh.uni-heidelberg.de) and include in one single PDF file your CV, copies of certificates and contact information for two referees.
Kontakt für Bewerbungen
Anne Schlaitz
email: a.schlaitz@zmbh.uni-heidelberg.de
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